Arizona Cardinals VS Jacksonville Jaguars Preview
The Arizona Cardinals host the Jacksonville Jaguars on November 23, 2025, at State Farm Stadium in Glendale, Arizona, with kickoff set for 4:05 PM MST. This NFL matchup pits a struggling home team against a visitor finding rhythm offensively. Arizona’s defense has been porous, while Jacksonville’s efficiency metrics suggest growing confidence heading into this contest.
The Cardinals enter with severe home struggles, posting a dismal 1-4 record at State Farm Stadium this season. Meanwhile, the Jaguars arrive relatively healthy and balanced, with Trevor Lawrence leading an offense that controls tempo and sustains drives. Injury uncertainty around Marvin Harrison Jr. compounds Arizona’s challenges, threatening an already inconsistent passing attack.
Early expectations favor the visitors in this interconference showdown. The Arizona Cardinals VS Jacksonville Jaguars game preview highlights Arizona’s defensive vulnerabilities and Jacksonville’s operational precision. The Arizona Cardinals VS Jacksonville Jaguars betting odds reflect a market leaning toward the road favorite, with Jacksonville positioned to exploit the Cardinals’ systematic weaknesses.
Key Factors for Arizona Cardinals VS Jacksonville Jaguars
Arizona’s defense has surrendered 85 points in their last two games, exposing critical gaps in coverage and discipline. The unit committed 17 penalties against San Francisco, illustrating a lack of focus. Jacksonville’s offense, by contrast, ranks first in success rate, yards per point, and third-down efficiency, creating a stark mismatch in operational quality.
Trevor Lawrence has completed 68.4% of passes over his last four outings, maintaining a 2.1 touchdown-to-interception ratio that signals improved decision-making. Jacksonville leads the NFL in time of possession at 32:45 per game and averages 16.6 yards per punt return, controlling field position and momentum. Their stabilized offensive line and post-bye efficiency provide structural advantages.
Marvin Harrison Jr. is questionable due to appendicitis, a potentially devastating blow for Arizona’s passing attack. The Cardinals are 1-4 at home this season, struggling to protect State Farm Stadium. The Arizona Cardinals VS Jacksonville Jaguars betting forecast and Arizona Cardinals VS Jacksonville Jaguars prediction both emphasize Jacksonville’s clear edge in health, consistency, and matchup leverage.
Recent Trends for Arizona Cardinals VS Jacksonville Jaguars
The road team has covered the spread in eight of the Cardinals’ last 10 games, underscoring Arizona’s inability to capitalize on home-field advantage. The Cardinals have lost each of their last nine games against teams with winning records, revealing systematic struggles against quality competition. These patterns suggest continued vulnerability.
Arizona has covered the spread in each of their last seven games as underdogs against AFC opponents, offering a contrarian angle. However, Jacksonville’s advanced metrics in efficiency and tempo suggest this trend may not hold. The Jaguars’ ability to control possession and convert third downs represents a tactical turning point in this matchup.
The Arizona Cardinals VS Jacksonville Jaguars matchup trends reveal a clear pattern of Arizona’s home struggles and Jacksonville’s growing operational momentum. The Arizona Cardinals VS Jacksonville Jaguars betting insights point to a visitor capable of exploiting defensive breakdowns, sustaining drives, and winning the field-position battle through special teams excellence and offensive discipline.
Our Prediction is Jacksonville Jaguars -3 spread
Jacksonville’s comprehensive efficiency advantages across success rate, third-down conversions, and yards per point create a clear path to covering the spread. Arizona’s defense has been hemorrhaging points, allowing 85 in two games, while struggling with penalties and assignment errors. The potential absence of Marvin Harrison Jr. further limits Arizona’s scoring potential.
Trevor Lawrence’s recent form, combined with Jacksonville’s league-leading time of possession and field position, positions the Jaguars to dictate game flow. Arizona’s 1-4 home record and nine-game losing streak against winning teams highlight systemic issues. The Jaguars’ post-bye health and offensive line stability provide tactical advantages across all three phases.
We believe the outcome of the match will be Jacksonville Jaguars -3 spread. The mismatch in defensive quality, offensive efficiency, and situational execution favors the visitors decisively. Jacksonville’s ability to control tempo and exploit Arizona’s penalty-prone defense makes this line attractive, despite the Cardinals’ modest ATS success as AFC underdogs.
Backed by data on form, injuries, and situational trends, this recommendation represents the most accurate and valuable call for this Arizona Cardinals VS Jacksonville Jaguars matchup. Jacksonville’s operational superiority and Arizona’s home struggles create a clear betting opportunity. The Arizona Cardinals VS Jacksonville Jaguars betting picks strongly favor the road favorite covering the three-point spread.
