HomeNCAA PicksSoutheast Missouri State VS Lindenwood Prediction: November 22, 2025

Southeast Missouri State VS Lindenwood Prediction: November 22, 2025

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Southeast Missouri State VS Lindenwood Preview

Southeast Missouri State hosts Lindenwood on November 22, 2025 at Houck Field in Cape Girardeau, MO for a 1:00 PM CT kickoff in the NCAA. This season finale brings intrigue as both teams look to close out their campaigns with momentum. SEMO leads the all-time series 2-1 but dropped last year’s meeting 24-12, making this a revenge spot for the Redhawks at home.

The Southeast Missouri State -1.5 spread reflects a tightly contested matchup expected to be decided by a single score. Quarterback uncertainty looms for SEMO after starter Jax Leatherwood missed the previous game with an ankle injury, forcing backup Johnny Weber into his fourth career start. Despite the question marks under center, the Redhawks possess offensive firepower and home-field advantage heading into this critical clash.

Early expectations suggest a low-scoring, competitive affair with projections hovering around SEMO 26, Lindenwood 25. Both Southeast Missouri State VS Lindenwood game preview analysis and Southeast Missouri State VS Lindenwood betting odds point toward a narrow margin separating these conference opponents in what should be a tightly contested final game with playoff implications on the line for both programs.

Key Factors for Southeast Missouri State VS Lindenwood

Southeast Missouri State ranks first in the OVC-Big South in passing offense at 272.6 yards per game, while Lindenwood sits third in league scoring at 24.3 points per game. The quarterback situation remains the biggest variable, with Leatherwood’s ankle injury status uncertain after missing last week’s action. Backup Weber has shown competence in limited duty but lacks the ceiling of the starter.

Running back Brandon Epton, Jr. is surging after posting a season-high 110 rushing yards in the previous contest, giving SEMO a reliable ground attack regardless of who lines up under center. No weather or field complications are expected at Houck Field, meaning conditions will favor the more disciplined and physical team. The all-time series edge belongs to SEMO at 2-1, though Lindenwood won convincingly last season 24-12.

The Southeast Missouri State VS Lindenwood betting forecast hinges on SEMO’s ability to protect home turf and overcome a three-game season finale losing streak. The Southeast Missouri State VS Lindenwood prediction accounts for Lindenwood’s offensive consistency against SEMO’s pass-heavy scheme, creating a clash of styles that should produce a high-intensity, closely matched contest with minimal separation on the scoreboard.

Recent Trends for Southeast Missouri State VS Lindenwood

Southeast Missouri State has struggled in season finales, dropping three consecutive final games and carrying that negative momentum into this matchup. Lindenwood captured last year’s meeting 24-12, exploiting SEMO’s defensive vulnerabilities and controlling time of possession. The Redhawks’ pass-first identity has delivered consistent yardage but hasn’t always translated to wins in high-pressure spots, raising questions about their clutch execution.

Lindenwood’s offensive balance makes them dangerous in tight games, and their third-ranked scoring attack has produced consistent points throughout the season. SEMO’s home-field advantage at Houck Field could prove decisive, but the pattern of late-season struggles cannot be ignored when evaluating situational trends. Both teams have shown flashes but also critical inconsistencies, making this a genuine toss-up from a momentum perspective.

The Southeast Missouri State VS Lindenwood matchup trends reveal a competitive rivalry with razor-thin margins in recent years. From an Southeast Missouri State VS Lindenwood betting insights standpoint, the projected one-point margin and small spread reflect the uncertainty surrounding both rosters, particularly with SEMO’s quarterback health in question and Lindenwood’s ability to capitalize on opponent mistakes in crucial moments throughout their campaign.

Our Prediction is Southeast Missouri State -1.5 spread

Southeast Missouri State covers the -1.5 spread in a narrow home victory fueled by Epton’s rushing momentum and the league’s top passing offense. Even if Weber starts at quarterback, the Redhawks’ offensive scheme and superior aerial attack give them the edge in execution. Home-field advantage at Houck Field provides the final margin, allowing SEMO to snap their season-finale losing streak in dramatic fashion.

The projected 26-25 scoreline aligns perfectly with the -1.5 spread, suggesting a one-score game decided late. SEMO’s pass-heavy identity exploits Lindenwood’s secondary vulnerabilities, while Epton’s ground production keeps the offense balanced and unpredictable. Lindenwood’s scoring capability ensures they’ll remain competitive, but SEMO’s desperation to avoid a fourth straight finale loss provides the intangible motivation required to cover the narrow number.

We believe the outcome of the match will be Southeast Missouri State -1.5 spread. The Redhawks’ offensive firepower, home-field edge, and all-time series advantage outweigh concerns about quarterback health and finale-game struggles. Epton’s breakout performance and 272.6 passing yards per game create enough offensive diversity to edge Lindenwood in a tightly contested finish that validates the small spread.

Backed by data on form, injuries, and situational trends, this recommendation represents the most accurate and valuable call for this Southeast Missouri State VS Lindenwood matchup. The combination of offensive firepower and home momentum gives SEMO the slight edge needed to cover and secure victory. For Southeast Missouri State VS Lindenwood betting picks, the -1.5 spread offers solid value in what projects as a one-score thriller.

Mason Bennett
Mason Bennett
I’m the voice behind Pick 60 Sports, a long-running U.S. platform built on data-driven analysis and expert picks across the NFL, MLB, NHL, CFL, NBA, soccer, UFC, and tennis. My focus is turning stats into smart, actionable insights for sports fans who bet with strategy.
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